YKL-5-124 TFA Catalog No.:M14492-2 induces glioma cell apoptosis through

induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

KI-20227 suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model

Antimycin A3

24 hours) inhibits phosphorylation of JAK2 and STAT3 (Tyr705 and Ser727) in LPS-induced RAW264

YKL-5-124 TFA Catalog No.:M14492-2 induces glioma cell apoptosis throughYKL 5 124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53. 5 nM and 9. 7 nM for CDK7 and CDK7 Mat1 CycH, respectively. YKL 5 124 TFA is >100 fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL 5 124 TFA induces a strong cell cycle arrest, inhibits E2F driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status. Product information